【Purpose/significance】Strengthen the cultivation of information literacy can improve college students’ ability todistinguish information, it will be of great significance for college students to stick to the moral bottom line and become use-ful talents for the society.【Method/process】Through the analysis of the information literacy education of college studentsat home and abroad, and the characteristics of college students’ information literacy,the paper constructs an information lit-eracy training mode of college students which is oriented by of innovation and entrepreneurship in "Internet plus" era.【Re-sult/conclusion】 With the application of modern technology resources, librarians and services can be integrate into theteaching, scientific research and life of teachers and students. Taking teachers and students as center; emphasizing theclose interaction of resources, teaching, scientific research, teachers, students and librarians, is an effective way to improvestudents’ information literacy.