The present study explored the relationship between parent-child attachment and adolescents’ internalizing and externalizing problems, as well as the serial mediation of resilience and resistance to peer influence. In total, 1029 junior school students in Jilin Province were investigated with the Inventory of Parent and Peer Attachment, Short Form of the Resilience Scale, Resistance to Peer Influence Scale and Youth Self-Report. Results showed that: 1) Compared with externalizing problems, parent-child attachment had a greater impact on internalizing problems of adolescents. 2) Resistance to peer influence played a mediating role in the relationship between parent-child attachment and adolescents’ internalizing and externalizing problems. However, compared with internalizing problems, the protective effect of safe parent-child attachment on externalizing problems was greatly enhanced through the mediation of resistance to peer influence. 3) Resilience and resistance to peer influence had serial mediating effects in the relationship between parent-child attachment and adolescents’ internalizing and externalizing problems.