The present study explored the relationship between early cumulative family risk and internalization problem of adolescents and its psychological mechanism. A total number of 780 teenagers were surveyed by using the cumulative family risk scale, personal growth initiative scale, perceived social support scale and YSR-CV. The results indicated that: 1) the cumulative family risk was significantly associated to internalization problems of adolescents; 2) the personal growth initiative and perceived social support parallelly mediated the link between cumulative family risk and internalization problem. The present study uncovered the potential mechanisms between cumulative family risk and internalization problems, which had certain significance of preventing and intervening problem behavior among adolescents.