Objective: The purpose of this study was to explore the relationship between mental health and the adjustment difficulties encountered by Thai and Filipino workers in Taiwan. Methods: By purposive sampling, 320 foreign workers from three petrochemical factories in southern Taiwan were recruited for this self-administered questionnaire survey. A self- constructed questionnaire inquiring into the demographic background and various possible encounter-adjustment difficulties was used together with the Chinese Health Questionnaire (CHQ) to obtain data on possible adjustment difficulties were applied for the measure. Results: The results showed that 51.2% of the subjects had poor mental health status. Workers who were young, female, or from Thailand and, in addition, those suffering from more serious adjustment difficulties were all more likely to have poor mental health status, especially those lacking social interaction, and those suffering from poor job conditions and anticipatory discrepancy. A stepwise m u ltiple logistic regression showed that nationality and job conditions were the most significant variables associated with mental health status in these foreign laborers. Conclusion: The results of this study suggest that the implementation of workplace intervention programs for improving the mental health of Thai and Filipino workers in Taiwan should be considered.