It is a extremely competitive times in the new centuary, and also is a Knowledge Economy times. Knowledge and wisdom are becoming most important capitals. If someone could own new knowledge, apply new knowledge, create new knowledge, thus they will control the whole worlds. So the knowledge Economy management become a imperative issue in the school administrative organization. The purpose of the study was to explore the response strategy of school administrative organization in the Knowledge Economy Times. Literature analysis was used. First, analyze the development and the meaning of Knowledge Economy. Second, explore the successful knowledge management. Finally, the response strategy of knowledge Economy which was applied in the school administrative organization to be concluded below: 1. To reconstruct the school organization. 2. To construct the school culture which was trustful and shared. 3. To build a leaning organization-reinforce the knowledge innovation. 4. To utilize the Information Technology. 5. To introduce the knowledge management system. 6. To implement the creative teaching and to encourage innovation.