Over the past few years, many interpretation programs have been established around Taiwan. In view of the rapid increase of interpretation courses, however, their teaching objectives are still not clearly specified. In general, most colleges are incorporating interpretation skills into their foreign language courses, while professional interpreter training is left to specialized courses at graduate level. Although many interpretation scholars and teachers have claimed that the main purpose for college interpretation courses is to enhance students’ oral English proficiency, rather than to train professional interpreters, such as statement has not been sufficiently supported by empirical evidence yet. Thus, the purpose of this study was to determine if the interpretation instruction would improve student’s oral English performance. Through an experiment, learning outcome produced by an interpretation class and an oral English training class was compared and analyzed. Also, a questionnaire was filled out by students to elicit their responses to the interpretation instruction. The results of this study clearly support the notion that interpretation instruction could facilitate students’ acquisition of oral English skills, as well as promote students’ motivation and interests to learn English well. Theses research results may contribute to a better understanding of the role of interpretation classes in foreign language curriculum at college level.