Because of the property negotiable securities commodity layer upon layer links, the capital flows free by financial globalization and a lot grew in international securities deal, American sub-prime mortgage loan storm has influenced over the world. Banks entrust creditors' rights to certain financial institutions for securitization, and then divide them to sell. Furthermore, the Mortgage Backed Securities (MBS) pool the other bonds into Collateralized Debt Obligation (CDO), and then sell to next layer of investors. Through asset securitization, banks and financial institutions are able to recall funds for re-investment. However, when the rate of breaking mortgage loan rises, the loose extend into layer upon layer of investors all over the world. This study is to discuss the spread processes and influence of American sub-prime mortgage loan to the global economy.