The purposes of the study were (1) integrating sounds, assistive technology of physical movement to help the development of physical movement of children with multiple disabilities and visual impairment; (2) inventing parity and local equipment of tactile sensory to enhance the development of physical movement of children with multiple disabilities and visual impairment. The methodology was both of qualitative and quantitative study. Seven 4-6 year-old participants with multiple disabilities and visual impairment were selected by purposive sampling to participate in the study. The duration was 6 months with 40-minute instructional sessions once per week. The data analysis was through semi-structured observation forms and anecdotal logs. Through a series of systematic music activities with Soundbeam equipment, the results of the study were as follows: 1.The participants’ ability of physical movement had a positive improvement. The social validity also showed the positive support for the result. 2.The invention of parity and local equipment of tactile sensory was able to assist the participants’ development of physical movement. The results showed the effectiveness of the music activities and the invented equipment on developing physical movement of children with multiple disabilities and visual impairment.