The development of the social work profession in Macau is closely-knitted to the social conditions before and after the handover. Macau has experienced two systematic movements of professionalization. The first was striving to establish the social work profession before the handover in response to the transition problem of professional qualifications after the handover. The second movement, promoted by the government after the handover, aimed at establishing a perfect system for social work profession to respond to the social needs. Its main task was to establish the legal system of social worker registration, which was expected to be completed in 2015. At present, the social work profession in Macau is at the stage of maturation. In response to the solid stage after the establishment of the registration system, ten problems need to be confronted and addressed.