This study aimed to explore the effect of family support, youth maltreatment, and social participation on adolescents' well-being with gender differences. The research used the data from the Taipei City Children and Adolescents' Living Conditions Survey in 2019 for analysis, with family support as the independent variable, youth mistreatment and social participation as the mediating variables, adolescents' well-being as the dependent variable, and gender as the moderating variable. Results indicate that family support and social participation affect adolescents' well-being; however, youth maltreatment has no effect on their well-being. There are no gender differences within this model. Based on the results, conclusions and suggestions were made.