Based on social comparison theory, the present study constructed a moderated mediation model to examine whether social network site use would be indirectly related to adolescents ′ happiness through negative social comparison, and whether this indirect association would be moderated by social anxiety. A total of 964 middle school and junior high school students(mean age=14.55 years, SD=1.09) were invited to take part in this study.Participants anonymously completed the Scale for Social Network Site Use Intensity, Negative Social Comparison Questionnaire, Social Anxiety Questionnaire and Subjective Happiness Questionnaire. The results showed that: 1)The negative association between social network site use and adolescents ′ happiness was mediated by negative social compari son. 2) The mediating effect of negative social comparison was moderated by adolescents ′ social anxiety, with the indirect effect was enhanced among high socially anxious adolescents. These findings suggested that both indirect-effect model and interaction model exist in the relationships of social network site use and adolescents′ happiness, creating a moderated mediation model.