In order to test the relationship among junior high school students’ interpersonal relationship, social self-concept, sense of coherence and optimistic tendency, 1040 junior high school students in Liaoning province were investigated by using adolescent optimism scale, teacher-student relationship scale, peer relationship scale, social self-concept scale and the sense of coherence scale.The results showed that there were significant positive correlations among teacher-student relationship, peer relationship, social selfconcept, sense of coherence and optimistic tendency. School interpersonal relationship, social self-concept and sense of coherence positively predicted the optimistic tendency. Social self concept and sense of coherence played multiple mediation roles between school interpersonal relationships and optimistic tendency.