The primary purpose of this paper is to examine various policies and practices of the student outcome assessment applied in the U.S. colleges and universities to assure the quality of college students. It is generally conceded that student outcome assessment is an effective instructional process, as well as a driving force, for achieving high quality of teaching and learning, as advocated in the No Child Left Behind Act and its related policy guidelines. For this reason, colleges and universities could employ various kinds of assessment to screen and sort students for appropriate curricular placements, to assist teachers in improving their teaching, and subsequently to assure that students would meet certain learning standards by the time they graduate. The information synthesized in this paper should be of value to the higher education community in Taiwan that is highly concerned about the lowering quality of college students. It offers various approaches for colleges and universities to assure that students could truly benefit from college education.