This paper briefly reflects on the greatest challenges that Buddhism faces nowadays: "Globalization, Civil Religion and Religious Secularization." Also, it proposes that in facing the crisis resulting from these challenges, in addition to thought change, twelve goals that rebuild the global values have to be promoted so as to create the greatest opportunity for Buddhism to have sustainable development: (1) setting up global ethic and promoting rebuilding of values; (2) confirming a balanced development between Globalization and Glocalization; (3) respecting multi-values and promoting interactions of multi-cultures; (4) protecting the holy assets of Buddhism and promoting cultural heritage education; (5) realizing the theory of "Non duality of body and earth" as well as promoting the green consumption; (6) promoting global lawmaking and preserving ecological resources; (7) redefining the concept of development and the three major roles of localized Buddhist centers; (8) participating actively in social issues like life education, physical and mental healing, and terminal care; (9) promoting diverse global public forums of Buddhism; (10) deepening the spirit of non-duality and promoting the intra-dialogue and inter-religious dialogue; (11) improving metta and karuna to eliminate different kinds of violence and (12) facing the global contracture of evil and directing to the right path.