Due to the recent rise of regional economic integration, there are many successful economic unions or free trade areas formed in Europe, North America, and Southeast Asia areas. Facing those rapid economic changes, Taiwan had to adjust itself to fit global trade trend and heighten the economic strength. Since 2009, Taiwan had started the trade negotiations with P.R. China and signed the ”Economic Cooperation Framework Agreement” (ECFA) in order to participate the progress of economic integration in East Asia. On the other hand, P.R. China also intends to strengthen the political and economic connection with Taiwan by cross-strait trade negotiations. Generally speaking, ECFA is a framework agreement and the details of implementation and related issues are waiting for future negotiations via a new established Economic Cooperation Committee. Amongst ECFA's issues, the rules and procedures of dispute settlement mechanism had been caught the world's eyes. The article therefore plans to analyze and compare the models of dispute settlement mechanism among the WTO, the European Union (EU), the North American Free Trade Agreement (NAFTA), Southeast Asia Nations (ASEAN) and Closer Economic Partnership Arrangement (CEPA) to debate the future establishment of ECFA's dispute settlement mechanism. Meanwhile, the formations of dispute settlement mechanisms in the EU and NAFTA are more rule-oriented and the modes of the ASEAN and CEPA are based on political consultation. Those different styles have some advantages in one way and weaknesses in the other way. Through the analysis and comparison of those different styles, the article hopes to make some recommendations in the field.