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題名：慢性腎病血脂蛋白變異與體重指數、空腹血糖、糖化血紅蛋白及胰島素抵抗的相關性研究
書刊名：澳門科技大學學報
作者：楚曼／王依滿／陳曉旋／崔紹漢／黃振國／林偉基
作者(外文)：Chu, Man／Wang, Angela Yee-moon／Chan, Iris Hiu-shuen／Chui, Shiu-hon／Wong, Chun-kwok／Lam, Christopher Wai-kei
出版日期：2013
卷期：7:1
頁次：頁133-138
主題關鍵詞：慢性腎病；血脂蛋白變異；相關性研究；Chronic kidney disease；Dyslipoproteinaemia；Association study
原始連結：連回原系統網址new window
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  • 點閱點閱:17
目的：研究慢性腎病（CKD) 中血脂蛋白尤其是小型濃密低密度脂蛋白（sd-LDL) 與體重指數（BMI)，空腹血糖（FPG)，糖化血紅蛋白（HbA1c) 及胰島素抵抗（IR) 的相關關係，探討代謝因數對血脂變異發生發展的意義。 方法：從香港招募234例根據KDIGO（Kidney Disease: Improving Global Outcomes，2004) 確診的CKD病人（年齡57 ± 12歲，男性人數=136)。酶解法或免疫法測定血清總膽固醇（TC)，甘油三酯（TG)，高密度脂蛋白膽固醇（HDL-C) ，直接低密度脂蛋白膽固醇（LDL-C)，空腹血糖（FPG) 及空腹胰島素（Abbott ci8200 analyzer)；FDA認許的聚丙烯醯胺凝膠梯度電泳法測定LDL類型和粒徑大小（Quantimetrix Lipoprint system)；親和色譜法測定HbA1c（Primus CLC 385 analyzer)；HOMA-IR（homeostasis model assessment-insulin resistance) 指數評估胰島素抵抗。 結果：TG與BMI，FPG，HbA1c和HOMA-IR 呈顯著性正相關（所有P
Objectives: To investigate the associations of dyslipoproteinaemia including small dense low density lipoproteins (sd-LDL) with body mass index (BMI), fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), and insulin resistance (IR) in chronic kidney disease (CKD) patients. Methods: 234 stage 3-5 CKD patients (age 57 ± 12 years, male=136) diagnosed according to KDIGO (Kidney Disease: Improving Global Outcomes, 2004) were recruited from Hong Kong. Serum total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), direct low density lipoprotein-cholesterol (LDL-C), FPG and insulin were assayed on the Abbott ci8200 analyser. LDL particle size was determined by FDA-approved polyacrylamide gradient gel electrophoresis (Quantimetrix Lipoprint system), and HbA1c by affinity chromatography (Primus CLC 385 analyzer). IR was estimated according to the homeostasis model assessment-insulin resistance (HOMA-IR) index. Results: TG was correlated positively with BMI, FPG, HbA1c and HOMA-IR (all P
期刊論文
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