According to Article 46 of Medical Care Act, medical care corporate shall allot at least twenty percent of the annual medical care income for medical research and development as well as community services. As a nonprofit organization, medical care corporate is committed to serving the public benefit, and its net earning shall not inure to the benefit of any individual. Recently, however, many medical care corporates were involved in fraudulent financial reporting, improper self-dealing and related party transactions scandals. The core issue remains that medical care corporates possess large amounts of medical resources and tremendous social impact, yet the government takes a comparatively loose regulatory approach. The corruption in healthcare sector results in medical waste, affecting the performance of the healthcare system and the quality of medical care. Without establishing an effective external supervision mechanism, the incentives for medical care corporates to exert self-control would certainly be reduced. Consequently, nonprofit organization may operate for the benefit of related parties and against public interest By comparing the governance of nonprofit healthcare organizations in the United States, this thesis aims to analyze the legal nature of medical care corporate, and the effectiveness of internal and external supervision mechanisms to prevent corruption in medical care corporates. Moreover, in order to integrate practice with theory, this thesis also conducts empirical research by interviewing professionals in the healthcare industry to examine the corruption issues in medical care corporates more comprehensively. Through the research in theory and in practice, this thesis would like to provide useful and practical suggestions for future law amending to establish sound anti-corruption supervision mechanism in medical care corporate.