This article discusses how the educational philosophy change would affect the instructional design and the learning strategies for computer-assisted-instruction (CAI). Behaviorism emphasizes the transferring of knowledge. Content experts develop the curriculum and educational technologists implement the materials onto the computers. When educational philosophy is gradually shifted to constructivism, CAI is expected to allow students to explore and evaluate their knowledge system. Under this paradigm, the nature of the contents becomes the main factor which determines how technologies should be used. The impact requires educational technologists to directly face the research in the fields of content learning and technology applications. Only in this way can content and technology be integrated appropriately to maximize the effects of educational technology. This article uses science education as an example to discuss the Chain model which is used to illustrate the integration of contents and educational technologies.