Taiwan relies heavily on international trade; especially, Taiwan has a very close industry and trade relationship with China. As a result, an empirical study about the currency exchange of Taiwan, China and U.S.A. becomes a very important issue. Contrasting to previous study, this study simultaneously adopts VEC、VAR and Granger causality model to establish exchange and macroeconomic factors model. Empirical finding supports the co-integration relationship in currency exchange of Taiwan、U. S. A and China. Renminbi is affected by interest rate and inflation rate. The exchange rate of New Taiwan Dollar is affected by lagged exchange rate and lagged interest rate; the interest rate of Taiwan is affected by lagged interest rate and lagged U.S.A interest rate. Granger causality analysis shows that interest rate and exchange rate mutually influence each other in Taiwan. U.SA. government and China government both adopts interest rate to control inflation rate.