The purpose of this study was to investigate the self-awareness, attitude,self-efficacy and behavioral intention in the senior high boy-girl relationship with the intervention of the interactional multi-media teaching on life skills and to assess the process of the intervening teaching program in the experimental group. The statistical methods included Chi-Square test, Paired-Samples T test and One-Way ANCOVA.The results were as follows:1. After the intervention, students of the experimental group had significantly improved , in respect of “self-awareness”, “attitudes”, “self-efficacy” and “behavioral intention”.2. Excluding the effect of the pre-test score (covariance) on the post-test score (variance), the experimental group’s “self-awareness”, “attitudes”,“self-efficacy” and “behavioral intention” of the life skills in the boy-girl relationship were significantly higher than those of the control group.3. Approximately 74% of the students in the experimental group enjoyed the activities designed in this multi-media program. Seventy-nine percent of the students indicated that the multi-media program “help them understand the life skills in the boy-girl relationship”, “establish the positive attitude in the boy-girlrelationship” and “have more confidence in self-efficacy in a healthy boy-girl relationship”. Furthermore, the students were willing to perform in the future those positive behaviors demonstrated in this multi-media program. This indicates that most of the students had affirmation on this well-designed health education program.In conclusion, the interactional multi-media teaching on the life skills in the boy-girl relationship recommended serves as a favorable method in practical sexuality education .