The increased rate of HIV infection in young people aged between 15-24 years old and lack of sexual health promotion programs in college reveals the urgency of sexual health promotion education in colleges. The project is to explore and further evaluate the process and the effectiveness of the sexual health promotion plan in campus. The project built the campus sexual health promotion program based on six areas of the campus health promotion. The program last 10 months with six subprograms, including teachers and students' empowerment on campus sexuality education, sexuality education courses, multi-gender and true-love lecture series, out of school sex education, health consultation clinic, and AIDS counseling and caring campus activities. The participants were chosen at random with recruitment and enrollment based on their freedom of choice for each sub-activity. A total of 3,978 participants were involved in the project. Paired t-test analysis was used to evaluate the project. The results revealed that the teachers who underwent a series of empowerment programs showed significant improvement on their difficulty feeling to reach teaching goal of sex education topics (t=-2.276, p<.05) and their attitudes and self- teaching performance of teaching the sexual education topics to students (t=2.837, p<.05); the students who participated the program expressed significant improvement on their sexual awareness (t=-8.061, p<.001), sexual knowledge (t=-28.738, p<.001), premarital sex attitudes (t=2.615, p<.05 ), and life skills of the male-female relationship (t=4.174, p<.001). The results of the sub-activities also revealed the positive responses. This project displayed that a sexual health promotion program based on health promotion school model is feasible and effective to integrate school internal and external resources to enhance the cognition, attitude, and self-efficacy of teachers and students in sexual health issues.