Purpose: The purpose of the study was to explore the effects of elementary school students with intellectual disabilities who improve skill ability applied physical activity with tee ball teaching and how about its retention effect. Methods: Three elementary school students with mildly mental retardation were chosen to participate in this study. The subjects were taught 24 times tee-ball teaching activities for four times a week. The study collected the data including the distance of throwing and throwing skills before and third, sixth week during the period of teaching and third week after teaching. The throwing skills were evaluated using the Burton's amendment (1992) of development sequences for overhand throw. The study used the single experiment design of the multiple probe design across subjects' method. Results: The results were as follows: 1. The physical activity with tee ball teaching not only improved the three participants' throwing distance, but had good retention effect as well. 2. The physical activity with tee ball teaching indeed improved the three participants' throwing skills and also had good retention effect except for subject B. After further analysis, the throwing skills including forearm, upper arm and trunk rotation improved better after teaching. Conclusion: It was concluded that the physical activity of tee ball teaching could improve the throwing distance and skills of elementary school students with intellectual disabilities and remained its retention effect as well. The instruction in physical education will be an effect factor influencing mental retardation students in future.