The authors reported the nursing experience of a patient with terminal stages of colorectal cancer in this article. The palliative care period was from 22nd of May to 11th of June, 2012. The evaluation information was collected through observations, physical examinations, and interviews. To have a holistic understanding, the inventories of palliative care were also used, including physical, psychological, social, spiritual, and good-death domains. The main health and care problems of this patient were recognized as pain, a wish-fulfillment, and her families' anticipatory grief. To relief her suffering, the palliative care team provided acupressure massages and aromatherapy to ease her pain. We also actively assisted the patient and her families to express feelings authentically, and accompanied the families to face their grief as well as the dying process of their loved one. In the end of her life journey, the palliative care team worked with her family to fulfill her final wish of cornea donation, which continued her life in a meaningful form. The goals of "good death for the deceased" and "no regret for the bereaved" were achieved. This nursing experience may provide clinical nurses a standpoint to achieve the quality and meanings of end-of-life care, furthermore, to achieve the valued goals of palliative care and grief counseling.