This study explores how Polyurethane was used as the raw material to manufacture the skate wheels. The results were as follows: 1. TDI system had a higher tensile strength and toughness; MDI system had a higher density; in the case of the same material, the high hardness of the material had higher tensile strength, density and toughness. 2. In the case of the same material, high hardness of wheels had a lower coefficiency of friction, higher rebound and lower abrasive. 3. TDI system had a high coefficiency, lower abrasive and anti-fatigue tested wheels that had glue off; MDI system had a high rebound, anti-fatigue tested wheels that had no glue off. 4. The rebound of stack layer wheels was better than that of solo layer wheels.