本研究之目的在分析亞斯柏格症與高功能自閉症青少年問題行為之相關因素，期望藉由研究結果能提供擬定介入措施之依據，以提升臨床護理照護之品質。本研究屬縱貫式前瞻、觀察性因果關係研究，採立意取樣、於台灣北部某醫學中心精神科急性病房進行收案。資料收集採參與觀察法，由精神科資深護理師就收案對象臨床徵狀依「問題行為記錄表」進行資料收集，共計收案40名，每位個案被觀察次數最少1次、最多5次。經由廣義估計函數式（GEE）分析發現：「是否參加行為治療」是影響亞斯柏格症與高功能自閉症青少年問題行為之重要因素，有參加行為治療者比沒有參加者問題行為減少10.5%。根據以上結果，本研究提出護理應用及未來研究之建議。

The purpose of this study was to indentify factors related to problem behavior in adolescents with Asperger's Syndrome and high-functioning autism. The results have implications for designing interventions to prevent the occurrence of Asperger's Syndrome and high-functioning autism. In this study, prospective longitudinal and crossover study designs were used. Our research sample consisted of 40 people from the psychiatric day and acute wards of a medical center and was based on a purposive sample method. The number of observations for each case was determined on the basis of the number of patient hospital visits; one hospital visit was the minimum, whereas five hospital visits was the maximum. Research data were collected from the psychiatric senior nurse. The Problem Behavior checklist was used to evaluate the results. Data were analyzed by GEE. The results showed that age, BGAS, and the classification of disease level combined with other diagnoses and ever executing behavior modification were significantly correlated with problem behavior. After controlling for other significant variables, ever executing behavior modification remained statistically signifi cant. Problem behavior decreased by 10.5% in those who participated in behavior modification compared with those who did not. Implications for nursing practice and future studies were also suggested.