In this thesis, we surveyed 600 people with disabilities by using the questionnaires, and examined the mediating role of selfesteem in the relationship between perceived social support and life satisfaction of people with disabilities and whether this process was moderated by communication. The results indicated that: 1)Self-esteem completely mediate the relationship between perceived social support and life satisfaction. 2)The mediating role of self-esteem is moderated by communication, and the communication moderates the second half process of perceived social support-self-esteem-life Satisfaction. As a result, the effect of perceived social support on life satisfaction of people with disabilities is a moderated mediator. This research had a reference value to improve the life satisfaction of people with disabilities and guide the relevant theoretical research.