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題名:睡眠影響記憶鞏固的同步EEG-fMRI研究
書刊名:心理科學進展
作者:雷旭趙文瑞
作者(外文):Lei, XuZhao, Wenrui
出版日期:2016
卷期:2016(3)
頁次:327-334
主題關鍵詞:腦電-功能磁共振腦網絡記憶鞏固睡眠Simultaneous EEG-fMRIBrain networksMemory consolidationSleep
原始連結:連回原系統網址new window
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  • 點閱點閱:6
默認網絡是靜息狀態活動較強的大腦結構,它包含的海馬和內側前額葉兩個腦區是記憶鞏固的關鍵部位,同時靜息態也被證明伴隨有記憶鞏固現象,我們推測默認網絡是睡眠依賴記憶鞏固的核心結構。本研究擬借助同步EEG-f MRI在時空分辨率上的優勢,研究默認網絡參與睡眠依賴記憶鞏固的神經機制。包括:1)發掘默認網絡活動的電生理指標,應用EEG源定位和跨頻段耦合分析,揭示記憶鞏固的動態過程;2)應用滑動時間窗和模塊分析,研究默認網絡參與靜息態和睡眠過程記憶鞏固的異同,揭示記憶在晝夜更迭中得以強化的神經機制;3)通過多模態信息融合,揭示記憶類型和睡眠階段等因素對睡眠依賴記憶鞏固的影響。本研究的開展對闡明睡眠依賴記憶鞏固的神經機制具有深刻的理論意義,並最終可能為治療學習記憶相關障礙提供全新的思路。
The default mode network(DMN) is a brain structure persisting activity during the resting state. As resting state has been demonstrated with function of memory consolidation and sub-regions of DMN, the hippocampus and medial prefrontal cortex, are the key regions of memory consolidation, we hypothesize that the DMN is the core structure of sleep-dependent memory consolidation. With the high resolution in temporal and spatial domain of simultaneous EEG-f MRI, we will study the neural mechanisms of the DMN-involved memory consolidation, which includes: 1) describing the dynamic process of memory consolidation based on the EEG source localization and cross-frequency coupling analysis; 2) distinguishing the functional connectivity of DMN during resting and sleep states based on the sliding time-window and module analysis to reveal the basic principles of memory enhancement within the iteration of day and night; 3) revealing the influences of types of memory and sleep stages in memory consolidation by multimodel fusion. This project will not only develop new techniques for dynamic analysis of brain function, but it also has profound theory significance to elucidate the neural mechanisms of memory consolidation. Moreover it may ultimately provide new ideas for the treatment of the learning and memory related disorders.
期刊論文
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圖書
1.雷旭、堯德中(2014)。同步腦電--功能磁共振(EEG-fMRI)原理與技術。北京:科學出版社。  延伸查詢new window
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