The main goal of this research is to discuss the practical knowledge development for special education student teachers, aiming at investigating the development progress of teacher practical knowledge for case-study teachers. Two student teachers graduating from teachers college were picked up to participate in this research for case study, and then gather and analyze data by observation, inquiring, and document analysis. We have come to the following conclusions. First, the practical knowledge of special education teacher includes knowledge of self, pedagogical content knowledge, general pedagogical knowledge, content knowledge, knowledge of the milieu of teaching, and knowledge of learner. The practical knowledge of one teacher might be different with others’ due to his special character. The practical knowledge of these two student teachers is based on the knowledge of learner, and developed under various education contexts. Second, the development progress of practical knowledge for special education teachers includes four periods. They are the honeymoon period, the period of searching for material and ways of teaching, the crisis period, and period of learning to get by of failure. Third, practical knowledge is related to pre-career education, externship courses, and practical teaching activities, especially for those experiences of learning as a student, of the normal life, and of the training courses in teachers college. Externship is the key period for promotion of teacher practical knowledge. It is important to help those student teachers to be skill in this period. According to our conclusions, we give several suggestions to student teachers, teachers colleges, educational governments, and future researches.