The US-Taiwan-China bilateral relations deeply influence the cross-Strait relations. Hence, it is essential to search the greatest common denominator among the cross-Strait as well as the trilateral relationship. This paper will be divided into four parts to discuss. First, based on “One China Policy” and the “1992 Consensus”, we will analyze the cross-Strait political situation. Secondly, as US still plays a significant role m the interaction of cross-Strait relations, we will review American attitude toward the political and economic interaction between China and Taiwan. In addition, how will the American new “Anti- terrorism” perspective affect the political and economic interaction between cross-Strait as well. Finally, according to dilemma of the US-Taiwan-China and cross-Strait interaction encountering, some suggestions are provided for some policymaker as references.