The market demand for domestic aviation in Taiwan reached its peak in 1997 but started to slide down all the way after 1998. High-cost passenger aircrafts became a heavy burden for aviation companies, and the increasing construction of highways, the inauguration of high speed railway as well as the pressure of global recession in recent years all add the challenges to the operation management of domestic aviation industry. The research seeks to find out the survival factors affecting the operation of the domestic airline by utilizing the survival analysis to examine the variables combination of the frequency of flight, available seat, passengers carried, commercial course, recreation course and the repeated course place of the high speed railway and domestic airlines. The result provides an important reference and basis for airline executives to improve deficiency and serves as a future operation direction. The result of study is found that available seat, commercial course and the repeated course place of the high speed railway for the important survival factor to influence domestic airlines.