In recent years, the natural disaster caused large scale damages to the cultural heritages around the world. Traditionally, organizations of cultural custody have their social responsibility, and the valuable cultural heritages have to be preserved during various disaster. This paper mainly discusses the role of cultural custody organizations when faced natural disaster. During 311 Earthquake happened in Japan, the country’s cultural custody organizations implemented several rescue efforts to preserve cultural heritage. The experience of Japan and other countries should also serve as the reference of policy-making when facing crisis management of cultural heritage caused by natural disaster.