Although political and economic circumstances deteriorated in Tainan, its industrial base has since improved with the issuing of industrial law in 1960. The district has since been revived in 2010 with the merger of Tainan City and Tainan County. This paper aims to explore Tainan's historical and special manufacturing changes between 1966 to 2011. We offer to holistically explore Tainan's manufacturing development through four aspects: the growth index, the aggregation trend of symbol "入", the interdependency of location-urban development, and Tainan's other potentials.The growth index is computed from the number of factory, labor, and total output value from every district. The aggregation trend of symbol "入" is obtained by analyzing industrial indexes such as industrial strength, location quotient (L.Q.), and surplus labor-space analysis. The interdependency of location-urban development can be examined from city planning blueprints, distribution of industry maps, land use maps, traffic network maps, etc.Finally, the paper provides suggestions on "industrial zone-population center village" and "industrial zone-labor center of manufacturing village" in regards to future development trends in manufacturing in Tainan.