Purpose: This study was to examine the quality of life for National Taiwan University (NTU) students. Method: The participants were NTU students taking specialized PE courses during the first semester of the 100th academic year except freshmen, and a questionnaire survey was applied in this study. Objectives were selected by purposeful sampling. 1000 questionnaires were distributed, and 897 valid questionnaires were received. Descriptive statistic analysis, independent-samples t test, one-way ANOVA and LSD test were used for data analysis. Results: The physical component summary scales (PCS) of NTU students were higher than the mental component summary scales (MCS). Male students score higher than females except the concept of mental health (MH). Sophomore score lower in the concepts of vitality (VT), role-emotional (RE) and mental health (MH). Students taking PE course of group ball games are prior than others in the concepts of general health (GH) and vitality (VT). Compared to norms, NTU students score lower than averages not only from same age group but for all. Conclusion: NTU students show lower quality of life, might resulting from more academic pressure and social expectation. The advantages of PE courses should be emphasized more to enrich the leisure life of college students. More relevant variables could be analyzed for the following-up researches in order to get more integrated comprehension about the quality of life of college students.