OBJECTIVES: Cosmetic medicine has become quite popular; however, traditional dermatology clinics have focused only on the treatment of diseases and their overall revenue is far less than that of cosmetic medicine clinics. The aim of this study was to explore ways to transform the business model of traditional dermatology into that of cosmetic medicine, METHODS: In order to understand the differences in the business models of traditional dermatology clinics and cosmetic medical clinics, this study explored the related theories of business models, and selected the nine grid business model developed by Osterwalder & Pigneur as the main framework for analysis. This study also selected four cosmetic medical clinics which had successful transformed from traditional dermatology clinics, analyzed their business models, and then used the systems thinking model to portray their patterns of growth. RESULTS: Factors in traditional dermatology clinics which successfully transformed into cosmetic medicine clinics included the attractiveness of their advertising and sales, setting, counselors, doctors, and outcomes. CONCLUSIONS: A combination of the nine grid business model developed by Osterwalder & Pigneur and the systems thinking model helped us to understand the important mechanisms which drove the growth in the transformation of traditional dermatology clinics into cosmetic medicine clinics.