Aided by advances in global technology and innovation, medical sciences are progressing at a rapid pace. At the same time, population ageing has become a serious issue. Health awareness and the use of technological products are also increasing with the rising popularity of and improvements in information and communications technology. This presents an opportunity for smart healthcare to penetrate into the consumer market. As smart mobile devices have become commonplace and the application (App) market is continuously growing, mobile health applications (mHealth Apps) present business opportunities in the smart healthcare market. This study examines the services that can be assisted by mHealth apps. Based on the Extension of the Unified Theory of Acceptance and Use of Technology (UTAUT2) introduced by Venkatesh et al. (2012), it investigates nurses that incorporate mHealth apps into their practice and identifies their responses to mHealth apps. Effort expectancy, performance expectancy, compatibility and user habits of mHealth apps were all found to positively relate to behavioral intention. These findings can help app developers better understand nurses’ responses to smart healthcare sych that they can develop apps that can better meet the needs of nurses. This study also suggests qualitative research and quantitative research that could be conducted on policymakers of both medical and healthcare institutions, nursing staff, and general consumers to explore the psychological impact produced by mHealth Apps.