The sale of businesses is one primary means of business combinations or merger and acquisition. The market competition and interests of stakeholder groups, such as employees, creditors, suppliers and shareholders, may be impacted by sale of businesses. The main empirical problem in identifying the sale of businesses is how to define the uncertain concept of significant business or assets under the legal regime structured by Company Law, Merger and Acquisition Law, Fair Trade Law and Financial Regulation in Taiwan. This essay first discusses some of the basic concept involved in the sale of businesses .Section III introduces the some principal problems and debates between academicians and market participants. Section IV addresses some practical cases of assets acquisition and the issue of whether shareholder approval of such transfers is not required. Section V presents the restructure of sale of businesses from the prospective of corporate governance. Finally, a conclusion is drawn predicting the future regulation of sale of businesses.