Lu-xun commented on the different interpretations of A Dream of Red Mansions that, “classicists perceive Yi, Taoists perceive concupiscence, scholars perceive romance… ”, and likewise the interpretations of Journeyto the West. The Taoists such as Uang-dan-yi and Chen-shi-bin treated the story of Tang-san-zang going on a pilgrimage for Buddhists’ Scriptures as a metaphor of Taoists’ practice of forming pills, which has been the mainstream of interpretations since Ming Dynasty and Ching Dynasty. However, in addition to the practice to form pills interpretations, a Taoist priest would also interpret the story of going on a pilgrimage for Buddhists’ Scriptures with the Confucian classics such as Da-xue, Meng-zi and Zhong-yong. This essay takes as the text the remarks based on the Confucian doctrine in Chen-shi-bin “Xi-you-zhen-quan”, hang-shu-shen “Xin-shuo-Xi-you-ji”, Liu-yi-ming “Xi-you-yuan-zh”of Ching Dynasty to elucidate the writer’s points of view. It also explains that the principles of three cardinal guides and eight rules in Da-xue, provided with political and educational meaning following Song Dynasty and Ming Dynasty, were used by interpreters to interpret the comments on Journey to the West. This commenting method, beside Taoists’ “the way of Taoists’ practice to make pills” (金丹大道), is another cultural interpretations and comments similar to the style of preaching. Concerning the comments based on the Confucian doctrine, there are two points of significance deserving further exploration: one shows the phenomenon that the novel interpreters lean towards Confucian from Buddhism and Taoism under the atmosphere of the convergence of the three religions. Next, from the first comments on Journey to the West with the adherence to the concepts of ‘heart’ and ‘the cultivation of one’s original nature’ at the end of Ming Dynasty, to the concepts of ‘sit in silence’, ‘be discreet when alone’ presented by Chen-shi-bin during (Kang-xi) mid-Ching Dynasty and those followed to interpret Journey to the West, the comments based on the Confucian doctrine has gradually changed from Yang-ming philosophy of the mind to the philosophy of practice, which indicates that the interpreting standpoints change with the time, following the development of the trend of Confucian thought.