A. N. Whitehead (1861-1947) was one of the great metaphysicians in the twentieth century of the West who had assumed his position by inveighing against the torrents of anti-metaphysics, and by defending the importance and the necessity of metaphysics in the philosophical pursuit. As he once wrote in his Process and Reality, the general position of his philosophy of organism "seems to approximate more to some strains of Indian, or Chinese, thought, than to western Asiatic, or European, thought. One side makes process ultimate; the other side makes fact ultimate." Some contemporary Chinese philosophers were touched by these statements and trying to explore Whitehead's reasoning behind them. However, even before the publication of Process and Reality, as early as in 192, Thome H. Fang (1899-1977), when teaching philosophy at Central University, Nanking, Mainland China, noticed the ingenuity and significance of Whitehead's thought and its relevance to Chinese thinking. His student Shih-chuan Chen (1909-2005), following him, has been devoted to the comparative studies between Chinese philosophy and Whitehead's philosophy ever since he was an undergraduate of Central University. In their philosophical enterprise, Fang and Chen were convinced that Whitehead's philosophy of organism is communicable to Chinese in virtue of its organic mode of thinking and its core concept of creativity. The present paper is an attempt to deal with this earliest 'encounter' between Chinese philosophers and Whitehead from three perspectives, namely, Whitehead's understanding of Chinese thought, and Thome Fang's and Shih-chuan Chen's understanding of Whitehead's philosophy. We may find enough evidences in Fang and Chen's works to show that Whitehead had appreciated Chinese thought in the broadest sense, and they had shared their philosophical outlooks with him.