Purpose: This study explored the beneficial effects of the peer support group running for consecutive three years for the nursing staffs of the hospital-based hospice ward in Central Taiwan. Material and Method: This qualitative study recruited five nurses who had participated at least ten times among the support group members by a purposive sampling. They were invited to write down the experiences of transformation after they had participated the group using in-depth self-statements descriptions. We then did a qualitative analysis and interpretation of the contents. Results: The results were indicated that the beneficial effects of the peer support group on the nursing staffs can be summarized into two parts. The first part is the intrinsic and spiritual improvements which include awareness and acceptance of real-self, establishment of psychological boundaries, experience-blending with another, experiencing and empathizing the multi-facets of life, taking care of emotional and spiritual selves, and positive attitudes towards adversity. The second part is the external action changes which comprise seeking helps at appropriate time, smoother interpersonal relationship, and becoming an angel in another person's life. Conclusions: In summary, peer support group helped a hospice nurse advances from self-growth to better performance of works, furthermore, it played an influential role to produce an intrinsic transformation of the nurses' attitude towards life. The results may provide a learning mirror to the education and training in the aspects of personal growth and spiritual care for hospice nurses in certain hospitals.