At the school ages, the characteristics of students with learning disabilities are not obvious as those students with other disabilities. Determination of students with learning disabilities aims at selecting those students with learning disabilities and adopting the special education to them. In this study, artificial neural networks (ANNs) is applied to the determination of students with learning disabilities. Those students with learning disabilities can be detected well (the accurate rate is about 90%) by using the proposed approach. This enhancement of determination helps the practice of special education.