Medical education in Taiwan is deeply influenced by the Japanese and the American medical education systems. By incorporating these two systems with its own system and under the influence of its local medical environment and sociocultural background, a unique medical education system has developed in recent years. The cornerstone of medical education in Taiwan was laid during the Japanese occupation period. The Taiwan Governor Medical School was established in 1899 and was reorganized into a specialty school in 1919 and then into the Medical School of Taihoku (Taipei) Imperial University in 1936. During the Japanese occupation period, medical practice other than western medicine was prohibited. This created a relatively simple medical environment and uniform quality in education. The Medical School of Taihoku (Taipei) Imperial University was renamed National Taiwan University College of Medicine (NTUCM) in 1945 after the return of Taiwan to China. The curriculum required seven years to complete and admitted high school graduates. American curriculum and educational methods were introduced to NTUCM in 1951 and became operational in 1954. Afterwards, many private and public medical schools were gradually established. By the end of 1994, there were 10 medical schools in this country. Most of the medical schools follow the American educational model. However, under the constraints of government regulations and the lack of teaching faculty and facilities, the advantages of the American medical education system have not been fully developed. Taiwan has undergone abrupt social, political, and economic changes since 1970. Because of advanced medical technology and changes in disease patterns and the social environment, medical education has come to a truning-point. Traditional medical education is unable to meet the challenges of the future. In order to train physicians who can fulfill future requirements, medical education reform has become inevitable. In 1992, educational reform was initiated and a new curriculum was implemented at NTUCM. The objectives of the new curriculum were to promote basic clinical integrated courses and small group problem-based tutorials, and to reinforce teaching of medical ethics and humanities as well as the biopsychosocial approach to medical practice. The new curriculum emphasized life long self-learning to enable students to update their medical knowledge along with the progress of medicine. The educational reform at NTUCM gives a pattern for future training of physicians in Taiwan.