Great Mekong Sub-region( GMS) countries,namely Cambodia,Myanmar,Laos,Thailand and Vietnam holds crucial position in the Southeast Asia. Compared to ethnic relations in the rest of the world,it witnesses the uniqueness of diverse development with common origin,cross-border inhabitance,ethnic relationship and identity between the local Chinese and overseas Chinese formed in the long history and broad territory between China and GMS countries. The academic importance for the studies of the ethnic basis includes the co-existence,diversity and the in-depth exchange,communication interaction and integration among ethnic groups in both China and Southeast Asia. The realistic significance of the ethnic basis in this region is that it is favorable to overcome the Sino-centrism and its troubles.