Three emerging trends of global innovation and entrepreneurship include rapid industrial change and the reconstruction of innovation ecosystems, the wave of Silicon Valley firms in driving global entrepreneurship development, and the establishment of incubation accelerators, etc. This study concludes three major models in promoting entrepreneurship incubation through researching the international park, entrepreneurship incubation trend, government policy, and approaches from major countries. First, the government-led development model by Singapore and Israel: the governments have established early-stage venture capital, matching investment in new ventures, angel investment with tax credit, and establishing incubation accelerators to attract foreign incubation centers. Second, free market-oriented venture capital model by the Silicon Valley of the U.S.: Silicon Valley innovation cluster has been encouraging industry-academia R&D cooperation, establishing the most important venture capital cluster (with annual venture capital investment exceeding 6 billion USD), and creating incubation accelerators. Third, university-centric industry-academia cooperation by Cambridge Science Park of the U.K.: the science park has been promoting technology transfer between university and industry, creating venture businesses, and providing a highly interactive learning and opinion-sharing environment for entrepreneurs. Creating industrial incubation platform has become a very important international trend in deepening economic development. Taiwan now is facing the critical timing for upgrading economic and industrial structure. It is giving Taiwan the best opportunity to borrow the above experiences to ride on the current trends of global innovation and entrepreneurship to create industry-specified incubation accelerators, and to promote Start-Up Business, in order to reform its industrial structure as a whole.