The purpose of this research is trying to inquiry the effect of students learning in life science general education integrated with history and philosophy of science. The instruction notion is integrated with multiple these competition dynamic model in history of science which is rich in historical situations and humane cultivation. Then let students to assume themselves were scientists to experience multiple these competition dynamic course by discussion small groups. In order to confer the interaction of teacher's teaching and students' learning in this curriculum, to interpret student's progress in this curriculum, and to interpret student's felling in this curriculum. There is a significant effect in pre-and post-biological test. The analysis of the interview transcriptions shows that students' understanding the nature of science is more post-positivism The results of homework assessment shows that students make progess in the aspects of multiple these competition notion, association with science and humane learning, values introspection. 88% of the students express that their interest in learning life science may increase and indicate that diversification of teaching materials and homework allow them for reflecting what they have learned, discuss reports may promote thinking in many ways, and multimedia teaching increase learning outcomes etc. Especially, discuss in small groups can produce much more ideas and solve the problem of limitation in individual thinking, their ability of effective thinking and experience toward natural life become mature, their ability of appropriate decision and awareness of value become mature. Theses growths derive from homework assessments, discuss in small groups, teacher's guidance and multimedia teaching.