The implementation of vocational education curriculum incorporated by self-protection and Gender interaction was investigated by interviewing with special education vocational high school teachers in Hualien area. Data were collected by visiting 9 teachers of special education vocational high school. Semi-structured interview guidelines were designed by the researcher for this study. The collected data were analyzed by qualitative research method. The main findings include： (1) The interviewed teachers mentioned that the most important teaching topics were adequate vocational attitude, vocational skill training, vocational area understanding, and building up adequate social relationship. (2) The most frequently encountered situation were communication with the opposite gender, communication, and properly expression. The most difficult problem was sexual abuse of woman students. (3) Self-protection included relationship boundary, responding with the strangers, etc.The detail of gender communication included social skill, inter-respect, set up distances with others,etc. (4) Some students came from problem family. The difficulty was the students did not understand the boundary between genders. (5) After the implementation, the student attitude was positive. (6) The teaching resources included law, medical assistance, related resources provided by local area, helps from academic institute,etc. Based on the results, several suggestions were made in this study.