Competition in the field of business can be as fierce as that in war; not surprisingly then that tostrike their business opponents down by damaging their business reputation, some competitors often go to the extreme in every measure, such as by making or disseminating false statements. In light of the damage caused by such actions to business transactions, by formal decree, the Fair Trade Law of Taiwan prohibits any such kind of action. This essay first reviews the regulations concerning business defamation that exist in individual countries, and through case studies, it also explores the legislative purpose, statutory components, and the legal sanctions of the Fair Trade Law, Article 22. Equally important, in Taiwan, as in other countries, in order to protect the social reputation of a person, defamation is treated as a criminal offense. Because these actions not only damage the credibility of business opponents, but also work to undermine the credibility of the person in charge of a targeted enterprise, the Fair Trade Law, Article 22 imposes penalties for business defamation. In addition to discussing the contents of relevant regulations in some selected countries as well as the contents of the Fair Trade Law, Article 22, this essay explores the defamation regulations in the Criminal Law of Taiwan, thus shedding light on the relationship between the Fair Trade Law and Criminal Law.