Food product retail staff often assumes unnatural, repeated postures, which cause serious cumulative musculoskeletal injuries. This study explores the musculoskeletal injury conditions and possible hazards to retail staff and provide related improvements. The research first acquires basic information on workers and examines their musculoskeletal disorder symptoms using the effective Nordic Musculoskeletal Questionnaire. The working postures are video-recorded and saved to a computer to code the postures and analyze the injuries based on the Ovako Working Postures Analysis System. The Musculoskeletal Disorders checklist was used to estimate the musculoskeletal disorder scores and analyze danger factors for the upper limbs, back and lower limbs according to the MSD results. Using the NMQ survey the results show that for the 130 respondents, 90.77% of supermarket retail staff experienced musculoskeletal injuries. The shoulder (77.69%), neck (75.38%) and hand (63.85%) were the most serious. The OWAS work posture analysis system found that there were eight hazardous working postures that rated from AC2 to AC4. The MSD checklist of human factors found that the upper extremity part (Table 1.) scored 63.85% greater than or equal to 5 points. The back and lower extremities (Table 2.) scored 75.38%, suggesting that the back and lower extremities part have greater risk for musculoskeletal disorders. The main risk factors are repetitive work, improper work postures, excessive force and lack of assistive devices. Therefore, retail staff should pay attention to improving their working postures, use assistive devices and have long rest periods to reduce personnel risk for musculoskeletal discomfort.