The present study aimed at developing a mental health screening scale for college students. Based on theoretical analysis,surveys and expert assessment, we constructed a model with three levels and 22 dimensions, and subsequently developed scale items.Through the initial test of 890 normal college students and 67 clinical sample, the final test of another 810 college students, and several times of expert assessment, we examined and revised the scale items, and finally developed the college students mental health screening scale. Results showed that the constructed model of college students mental health screening scale was reasonable and feasible. And the discrimination indexes of the items, the reliability and the validity of the scale all reached the criterions of psychological assessment. In consequence, the college students mental health screening scale was a reliable and valid measurement tool.