Spiritual care is extraordinarily important for both hospice and holistic care, but it is always interwoven with psychological reactions and religions. The theme of this article is an attempt to use simple examples to demonstrate the differences and relationships among spirituality, psychological problems and religion to clarify people's misunderstanding. Spiritual growth does not only occur in terminal cases, but it also happens in the third stage of disease adaptation in non-terminal patients. Self-actualization, the top level of Maslow's hierarchy of human needs, is a manifestation of personal spirituality. Spirituality is a dimension of a person that is concerned with ultimate ends and values. It is also a personal philosophy and a value system. Spirituality tells us what meanings and purposes people are concerned about in their lives, social activities, and psychological responses. This kind of firm belief will influence personal attitudes and behavior, such as reactions to the 911 tragedy of The Worcd Trade Centeo, NY. buildings. In addition, it will affect an individual's coping skills, interpersonal relationships, and psycho-physiological health. Religion is a particular belief and worship system, having its own value system and rules. So, a religious individual or group shares the same beliefes, and behaves under the same constraints. Religious faiths are the only bases for loyal disciples, and they are the standards of spirituality. A man without healthy value systems in life will be lacking in spirituality, easily resulting in spiritual sufferings such as interpersonal conflicts, coping disabilities, and psychological distresses. This clarification of spirituality, religion and psychological problems will help all walks in spiritual care.