The main objective of this research was to investigate whether the career brunout was influenced by such factors like teacher's background, school's background, and the work stress interaction for the teacher who teach mental retarded children in elemantary schools, and how these factors could predict and explain the condition of career burnout. In this reserach, 171 of the teachers who teach mentally retarded children in elementary schools in Taichung City, Taichung County, Nantou County and Changhua County were tested in random sampling the results were as follows: 1.On account of the diffences of individual backgrounds (such as age, education level), the perception of work stress of the teachers teaching mentally retarded children in elementary schools in middle of Taiwan is boviously different. 2.On account of the diffences of school backgrounds (such as how many years the principal has served in the same school, the age of principal, and the location of a school), the perception of work stress of the teachers teaching mentally retarded children in elementary schools in middle of Taiwan is obviously different. 3.On account of the diffences of individual backgrounds (such as age, how many years the teacher has spent on teaching), the perception of career burnout of the teachers teaching mentally retarded children in elementary schools in middle of Taiwan is obviously different. 4.On account of the diffences of school backgrounds (such as how many years the principal has served in the the same school, the education level of the principal, and the location of a school), the perception of career burnout the teachers teaching mentally retarded children in elementary schools in middle of Taiwan is obviously different. 5.On account of the diffences of work stress, the perception of career burnout of the teachers who teach mentally retarded children in elementary schools in middle of Taiwan is obviously different. 6.For the teachers teaching mentally retarded children in elementary schools in middle of Taiwan, career burnout is obviously related to work stress; the heavier work stress is, the more serious career burnout is. 7.Administrative assistance is the best way to effectively predict the degree and times of career burnout, and the overall variance is 32.73%, 15.21%, and 19.26%. 8.There were canonical correlation between the career burnout and individual backgrounds, school background, and work stress.